Видимо после переезда на python3 отвалилась зависимость, без которой GUI не запускается: # virt-manager Traceback (most recent call last): File "/usr/share/virt-manager/virt-manager", line 20, in <module> from virtinst import util as util File "/usr/share/virt-manager/virtinst/__init__.py", line 44, in <module> from virtinst.distroinstaller import DistroInstaller File "/usr/share/virt-manager/virtinst/distroinstaller.py", line 12, in <module> from . import urlfetcher File "/usr/share/virt-manager/virtinst/urlfetcher.py", line 16, in <module> import requests ModuleNotFoundError: No module named 'requests' Установка пакета python3-module-requests помогает # rpm -q virt-manager virt-manager-1.6.0-alt1.git2549e6.S1.noarch